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XANAX® XR, CIV (alprazolam) Contraindications

CONTRAINDICATIONS

XANAX XR Tablets are contraindicated in patients with known sensitivity to this drug or other benzodiazepines.

XANAX XR is contraindicated with ketoconazole and itraconazole, since these medications significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A) (see CLINICAL PHARMACOLOGY, WARNINGS and PRECAUTIONS–Drug Interactions).

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